abstract：:Under conditions of mitochondrial calcium overload, especially when accompanied by oxidative stress, elevated phosphate concentrations and adenine nucleotide depletion, a non-specific pore, the mitochondrial permeability transition pore (MPTP), opens in the inner mitochondrial membrane. MPTP opening enables free passa...

journal_title：Journal of molecular and cellular cardiology

authors： Halestrap AP

更新日期：2009-06-01 00:00:00

abstract：:Aging enhances cardiac injury during ischemia and reperfusion compared to the adult heart, including in the Fischer 344 rat model of aging (F344). In interfibrillar cardiac mitochondria obtained from the elderly F344 rat, the rate of oxidative phosphorylation and the activity of electron transport complex III is decre...

journal_title：Journal of molecular and cellular cardiology

authors： Lesnefsky EJ,Minkler P,Hoppel CL

更新日期：2009-06-01 00:00:00

abstract：:Diabetes increases mortality and accelerates left ventricular (LV) dysfunction following myocardial infarction (MI). This study sought to determine the impact of impaired myocardial insulin signaling, in the absence of diabetes, on the development of LV dysfunction following MI. Mice with cardiomyocyte-restricted knoc...

journal_title：Journal of molecular and cellular cardiology

authors： Sena S,Hu P,Zhang D,Wang X,Wayment B,Olsen C,Avelar E,Abel ED,Litwin SE

更新日期：2009-06-01 00:00:00

abstract：:Diabetes is recognized as an independent risk factor for cardiovascular morbidity and mortality. This is due, in large part, to premature atherosclerosis, enhanced thrombogenicity and activation of systemic inflammatory programs with resultant vascular dysfunction. More enigmatic mechanisms underpinning diabetes-assoc...

journal_title：Journal of molecular and cellular cardiology

authors： Sack MN

更新日期：2009-06-01 00:00:00

abstract：:Mitochondria are central players in the pathophysiology of ischemia-reperfusion. Activation of plasma membrane G-coupled receptors or the Na,K-ATPase triggers cytosolic signaling pathways that result in cardioprotection. Our working hypothesis is that the occupied receptors migrate to caveolae, where signaling enzymes...

journal_title：Journal of molecular and cellular cardiology

authors： Garlid KD,Costa AD,Quinlan CL,Pierre SV,Dos Santos P

更新日期：2009-06-01 00:00:00

abstract：:Fibroblast growth factor receptor (FGFR) is expressed in a variety of cells and is involved in their proliferation/migration/survival. To elucidate FGFR-mediated specific action of vascular endothelial cells (ECs) on myocardial ischemia, we generated endothelium-targeted transgenic mice overexpressing constitutively a...

journal_title：Journal of molecular and cellular cardiology

authors： Matsunaga S,Okigaki M,Takeda M,Matsui A,Honsho S,Katsume A,Kishita E,Che J,Kurihara T,Adachi Y,Mansukhani A,Kobara M,Matoba S,Tatsumi T,Matsubara H

更新日期：2009-05-01 00:00:00

abstract：:In the human heart connexin(Cx)40, Cx43 and Cx45-containing gap junctional channels electrically couple cardiomyocytes, forming a functional syncytium. In the mouse heart, additionally, Cx30.2-containing gap junctions have been detected in the atrioventricular node where they are implicated, together with Cx45, in imp...

journal_title：Journal of molecular and cellular cardiology

authors： Kreuzberg MM,Liebermann M,Segschneider S,Dobrowolski R,Dobrzynski H,Kaba R,Rowlinson G,Dupont E,Severs NJ,Willecke K

更新日期：2009-04-01 00:00:00

abstract：:Endothelial dysfunction is the earliest pathologic alteration in diabetic vascular injury and plays a critical role in the development of atherosclerosis. Plasma levels of adiponectin (APN), a novel vasculoprotective adipocytokine, are significantly reduced in diabetic patients, but its relationship with endothelial d...

journal_title：Journal of molecular and cellular cardiology

authors： Cao Y,Tao L,Yuan Y,Jiao X,Lau WB,Wang Y,Christopher T,Lopez B,Chan L,Goldstein B,Ma XL

更新日期：2009-03-01 00:00:00

abstract：:Mouse embryonic stem cells (mESCs) differentiate into all cardiac phenotypes, and thus represent an important potential source for cardiac regenerative therapies. Here we characterize the molecular composition and functional properties of "funny" (f-) channels in mESC-derived pacemaker cells. Following differentiation...

journal_title：Journal of molecular and cellular cardiology

authors： Barbuti A,Crespi A,Capilupo D,Mazzocchi N,Baruscotti M,DiFrancesco D

更新日期：2009-03-01 00:00:00

abstract：UNLABELLED:Discrepant results for the phenotype of mitochondrial creatine kinase knockout mice (Mt-CK(-/-)) could be due to mixed genetic background and use of non-littermate controls. We therefore backcrossed with C57BL/6J for >8 generations, followed by extensive in vivo cardiac phenotyping. Echocardiography and in v...

journal_title：Journal of molecular and cellular cardiology

authors： Lygate CA,Hunyor I,Medway D,de Bono JP,Dawson D,Wallis J,Sebag-Montefiore L,Neubauer S

更新日期：2009-01-01 00:00:00

abstract：:The cardiac renin-angiotensin system (RAS) has been implicated in mediating myocyte hypertrophy, remodeling, and fibroblast proliferation in the hemodynamically overloaded heart. However, the intracellular signaling mechanisms responsible for regulation of angiotensinogen (Ao), a substrate of the RAS system, are large...

journal_title：Journal of molecular and cellular cardiology

authors： Lal H,Verma SK,Golden HB,Foster DM,Smith M,Dostal DE

更新日期：2008-12-01 00:00:00

abstract：:PICOT (PKC-interacting cousin of thioredoxin) was previously shown to inhibit the development of cardiac hypertrophy, concomitant with an increase in cardiomyocyte contractility. To explore the physiological function of PICOT in the hearts, we generated a PICOT-deficient mouse line by using a gene trap approach. PICOT...

journal_title：Journal of molecular and cellular cardiology

authors： Cha H,Kim JM,Oh JG,Jeong MH,Park CS,Park J,Jeong HJ,Park BK,Lee YH,Jeong D,Yang DK,Bernecker OY,Kim DH,Hajjar RJ,Park WJ

更新日期：2008-12-01 00:00:00

abstract：:The aim of this study was to determine if embryonic stem cell derived cardiomyocyte aggregates (ESdCs) can act as pacemakers in spontaneously active cardiomyocyte preparations when their connexin isoform expression is tuned toward a more sinus nodal phenotype. Using microelectrode array recordings (MEAs), we demonstra...

journal_title：Journal of molecular and cellular cardiology

authors： Fahrenbach JP,Ai X,Banach K

更新日期：2008-11-01 00:00:00

abstract：:The self-perpetuation of atrial fibrillation (AF) is associated with atrial remodeling, including the degradation of the myofibril structure (myolysis). Myolysis is related to AF-induced activation of cysteine proteases and underlies loss of contractile function. In this study, we investigated which proteases are invo...

journal_title：Journal of molecular and cellular cardiology

authors： Ke L,Qi XY,Dijkhuis AJ,Chartier D,Nattel S,Henning RH,Kampinga HH,Brundel BJ

更新日期：2008-11-01 00:00:00

abstract：:Nitric oxide, which is produced endogenously within cardiac myocytes by three distinct isoforms of nitric oxide synthase, is a key regulator of myocardial function. This review will focus on the regulation of myocardial function by each nitric oxide synthase isoform during health and disease, with a specific emphasis ...

journal_title：Journal of molecular and cellular cardiology

authors： Ziolo MT,Kohr MJ,Wang H

更新日期：2008-11-01 00:00:00

abstract：:Recent data indicate that the heart is a self-renewing organ and contains a pool of progenitor cells (PCs). According to the new paradigm, this resident population of multipotent undifferentiated cells gives rise to myocytes, endothelial cells, smooth muscle cells and fibroblasts. Understanding the function of cardiac...

journal_title：Journal of molecular and cellular cardiology

authors： Kajstura J,Urbanek K,Rota M,Bearzi C,Hosoda T,Bolli R,Anversa P,Leri A

更新日期：2008-10-01 00:00:00

abstract：:Cell-based therapy after myocardial infarction (MI) is a promising therapeutic option but the relevant cell subsets and dosage requirements are poorly defined. We hypothesized that cell therapy for myocardial infarction is improved by ex vivo expansion and high-dose transplantation of defined hematopoietic progenitor ...

journal_title：Journal of molecular and cellular cardiology

authors： Templin C,Kotlarz D,Faulhaber J,Schnabel S,Grote K,Salguero G,Luchtefeld M,Hiller KH,Jakob P,Naim HY,Schieffer B,Hilfiker-Kleiner D,Landmesser U,Limbourg FP,Drexler H

更新日期：2008-09-01 00:00:00

abstract：:Previous studies have shown that p53 plays an important role in maintaining cell cycle arrest of cardiomyocytes, which might account for the inability of human hearts to regenerate adequately after injury. Therefore, inhibition of p53 represents an attractive strategy to restore cell cycle progression in cardiomyocyte...

journal_title：Journal of molecular and cellular cardiology

authors： Ebelt H,Zhang Y,Köhler K,Xu J,Gajawada P,Boettger T,Hollemann T,Müller-Werdan U,Werdan K,Braun T

更新日期：2008-09-01 00:00:00

abstract：:Phosphorylation of myosin binding protein C (MyBP-C) was investigated in intraventricular septum samples taken from patients with hypertrophic cardiomyopathy undergoing surgical septal myectomy. These samples were compared with donor heart muscle, as a well-characterised control tissue, and with end-stage failing hear...

journal_title：Journal of molecular and cellular cardiology

authors： Jacques AM,Copeland O,Messer AE,Gallon CE,King K,McKenna WJ,Tsang VT,Marston SB

更新日期：2008-08-01 00:00:00

abstract：:Aspirin and clopidogrel are used therapeutically for their anti-platelet effects. We examined the effects of aspirin and clopidogrel on basal and beta-adrenoceptor (beta-AR)-mediated platelet nitric oxide (NO) synthesis in healthy subjects and patients with coronary heart disease (CHD). Healthy subjects (n=19) were ra...

journal_title：Journal of molecular and cellular cardiology

authors： O'Kane PD,Reebye V,Ji Y,Stratton P,Jackson G,Ferro A

更新日期：2008-08-01 00:00:00

abstract：:The goal of this study was to test the hypothesis that the novel anti-ischemic drug ranolazine, which is known to inhibit late I(Na), could reduce intracellular [Na(+)](i) and diastolic [Ca(2+)](i) overload and improve diastolic function. Contractile dysfunction in human heart failure (HF) is associated with increased...

journal_title：Journal of molecular and cellular cardiology

authors： Sossalla S,Wagner S,Rasenack EC,Ruff H,Weber SL,Schöndube FA,Tirilomis T,Tenderich G,Hasenfuss G,Belardinelli L,Maier LS

更新日期：2008-07-01 00:00:00

abstract：:We investigated the effects of viral infection on Tissue Factor (TF) expression and activity in mice within the myocardium to understand increased thrombosis during myocarditis. Mice were infected with coxsackie virus B3 (CVB3) and the hearts were collected at day 4, 8 and 28 post infection (p.i.). Myocardial TF expre...

journal_title：Journal of molecular and cellular cardiology

authors： Antoniak S,Boltzen U,Riad A,Kallwellis-Opara A,Rohde M,Dörner A,Tschöpe C,Noutsias M,Pauschinger M,Schultheiss HP,Rauch U

更新日期：2008-07-01 00:00:00

abstract：:Neural structures have been shown to be present in valve cusp tissue. We aimed to characterise the influence of neuronal stimulation on the component structures of the aortic root and cusps. Specimens of sinus, sinotubular junction (STJ), annulus and cusp tissue were dissected from porcine aortic roots and either stim...

journal_title：Journal of molecular and cellular cardiology

authors： Chester AH,Kershaw JD,Sarathchandra P,Yacoub MH

更新日期：2008-06-01 00:00:00

abstract：:Titin is a very large alternatively spliced protein that performs multiple functions in heart and skeletal muscles. A rat strain is described with an autosomal dominant mutation that alters the isoform expression of titin. While wild type animals go through a developmental program where the 3.0 MDa N2B becomes the maj...

journal_title：Journal of molecular and cellular cardiology

authors： Greaser ML,Warren CM,Esbona K,Guo W,Duan Y,Parrish AM,Krzesinski PR,Norman HS,Dunning S,Fitzsimons DP,Moss RL

更新日期：2008-06-01 00:00:00

abstract：:Almost 7 years have passed since the initial publication reporting that bone marrow cells regenerate infarcted myocardium. The subsequent years produced hundreds of investigations that ran the gamut of findings from validation to disproof. Undeterred by the concurrent debate, clinical trials ensued to test the safety ...

journal_title：Journal of molecular and cellular cardiology

authors： Sussman MA,Murry CE

更新日期：2008-06-01 00:00:00

abstract：:In this study, we looked into possible compensatory changes of other adenosine receptors (ARs) in A(2A) genetic knockout mice (A2AKO) as well as the functional role of nitric oxide (NO) in A(2A) AR-mediated vasodilation. Gene expression of ARs from coronary arteries of A(2A) AR wild type mice (A2AWT) and A2AKO was stu...

journal_title：Journal of molecular and cellular cardiology

authors： Teng B,Ledent C,Mustafa SJ

更新日期：2008-05-01 00:00:00

abstract：:The sulfur-containing beta-amino acid, taurine, is the most abundant free amino acid in cardiac and skeletal muscle. Although its physiological function has not been established, it is thought to play an important role in ion movement, calcium handling, osmoregulation and cytoprotection. To begin examining the physiol...

journal_title：Journal of molecular and cellular cardiology

authors： Ito T,Kimura Y,Uozumi Y,Takai M,Muraoka S,Matsuda T,Ueki K,Yoshiyama M,Ikawa M,Okabe M,Schaffer SW,Fujio Y,Azuma J

更新日期：2008-05-01 00:00:00

abstract：:Beta-adrenoceptor is over-stimulated during myocardial ischemia, in which hydrogen sulphide (H2S) concentration was found to be lowered. The present study attempted to investigate if H2S modulates beta-adrenoceptor function and the underlying mechanism. We examined the effect of NaHS (a H2S donor) on myocyte contracti...

journal_title：Journal of molecular and cellular cardiology

authors： Yong QC,Pan TT,Hu LF,Bian JS

更新日期：2008-04-01 00:00:00

abstract：:Heart failure patients have abnormal cardiac high energy phosphate metabolism, the explanation for which is unknown. Patients with heart failure also have elevated plasma free fatty acid (FFA) concentrations. Elevated FFA levels are associated with increased cardiac mitochondrial uncoupling proteins (UCPs), which, in ...

journal_title：Journal of molecular and cellular cardiology

authors： Murray AJ,Cole MA,Lygate CA,Carr CA,Stuckey DJ,Little SE,Neubauer S,Clarke K

更新日期：2008-04-01 00:00:00

abstract：:Fibroblast growth factor receptor 1 (FGFR1) is the only high-affinity FGFR in the vertebrate myocardium. FGFR1 is a tyrosine kinase receptor and has a non-redundant role in proliferation and differentiation of cardiomyocytes during embryogenesis. Results presented here demonstrate that FGFR1 gene expression declines a...

journal_title：Journal of molecular and cellular cardiology

authors： Seyed M,Dimario JX

更新日期：2008-03-01 00:00:00

abstract：:Adiponectin (APN), a recently discovered adipocytokine, is present in human serum in a full length (fAPN) and a globular form (gAPN). gAPN is a proteolytic cleavage product of fAPN and seems to show independent biological activities compared to the properties of fAPN. The influence of gAPN and fAPN on procoagulability...

journal_title：Journal of molecular and cellular cardiology

authors： Bobbert P,Antoniak S,Schultheiss HP,Rauch U

更新日期：2008-02-01 00:00:00

abstract：:The mechanisms responsible for myocardial dysfunction in the setting of sepsis remain undefined. Fas ligation with its cognate ligand (FasL) induces apoptosis and activates cellular inflammatory responses associated with tissue injury. We determined whether interruption of Fas/FasL interaction by cardiac-specific expr...

journal_title：Journal of molecular and cellular cardiology

authors： Niu J,Azfer A,Kolattukudy PE

更新日期：2008-01-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a complex disease that causes significant morbidity and mortality and is clinically characterized by an increase in pulmonary vascular resistance. The histopathology is marked by vascular proliferation/fibrosis, remodeling, and vessel obstruction. Development of PAH involves th...

journal_title：Journal of molecular and cellular cardiology

authors： Chan SY,Loscalzo J

更新日期：2008-01-01 00:00:00

abstract：:Inhibition of I(K1) currents by adrenergic alpha(1) receptors has been observed in cardiomyocytes and has been linked to arrhythmogenesis in an animal model. Both PKC-dependent and PKC-independent pathways have been implied in this regulation. The underlying molecular mechanisms, however, have not been elucidated to d...

journal_title：Journal of molecular and cellular cardiology

authors： Zitron E,Günth M,Scherer D,Kiesecker C,Kulzer M,Bloehs R,Scholz EP,Thomas D,Weidenhammer C,Kathöfer S,Bauer A,Katus HA,Karle CA

更新日期：2008-01-01 00:00:00

abstract：:During pressure overload hypertrophy, selective changes in cardiac gene expression occur that regulate growth and modify the structural and functional properties of the myocardium. To determine the role of translational mechanisms, a murine model of transverse aortic constriction was used to screen a set of specified ...

journal_title：Journal of molecular and cellular cardiology

authors： Spruill LS,Baicu CF,Zile MR,McDermott PJ

更新日期：2008-01-01 00:00:00

abstract：:Recovery of intracellular Ca transients and fractional shortening during late phase acidosis are suggested to be associated with CaMKII-dependent processes of which phospholamban (PLB) phosphorylation may play an important role. To test whether increased expression levels of CaMKII may further enhance recovery, we inv...

journal_title：Journal of molecular and cellular cardiology

authors： Sag CM,Dybkova N,Neef S,Maier LS

更新日期：2007-12-01 00:00:00

abstract：:Cardiac ventricular responsiveness to serotonin appears in rat postinfarction congestive heart failure (CHF), mainly mediated by 5-HT(4) receptors in chronic dilated CHF and 5-HT(2A) receptors in acute CHF. To differentiate between the effects of left ventricular (LV) hypertrophy and failure on 5-HT(2A)- and 5-HT(4)-m...

journal_title：Journal of molecular and cellular cardiology

authors： Brattelid T,Qvigstad E,Birkeland JA,Swift F,Bekkevold SV,Krobert KA,Sejersted OM,Skomedal T,Osnes JB,Levy FO,Sjaastad I

更新日期：2007-12-01 00:00:00

abstract：:Activation of both mTOR and its downstream target, S6K1 (p70 S6 kinase) have been implicated to affect cardiac hypertrophy. Our earlier work, in a feline model of 1-48 h pressure overload, demonstrated that mTOR/S6K1 activation occurred primarily through a PKC/c-Raf pathway. To further delineate the role of specific P...

journal_title：Journal of molecular and cellular cardiology

authors： Moschella PC,Rao VU,McDermott PJ,Kuppuswamy D

更新日期：2007-12-01 00:00:00

abstract：:Therapeutic angiogenesis can be induced by the implantation of bone marrow cells (BMCs). However, the mechanism of BMC-mediated neovascularization remains to be clarified. We investigated the differential activities of bone marrow subpopulations in angiogenesis and cytokine production. BMCs were separated into positiv...

journal_title：Journal of molecular and cellular cardiology

authors： Miyamoto Y,Suyama T,Yashita T,Akimaru H,Kurata H

更新日期：2007-11-01 00:00:00

abstract：:We report a novel action of intracellular adenosine monophosphate (AMP) to inhibit beta-adrenergic signaling in isolated rat ventricular myocytes. Extracellular application of adenosine or AMP suppressed isoproterenol (Iso)-induced prolongation of action potential duration (APD). This effect was completely abolished b...

journal_title：Journal of molecular and cellular cardiology

authors： Ogura K,Miake J,Sasaki N,Iwai C,Bahrudin U,Li P,Kato M,Iitsuka K,Hirota Y,Koshida T,Yamamoto Y,Inoue Y,Yano A,Adachi M,Igawa O,Kurata Y,Morisaki T,Shiota G,Shirayoshi Y,Haruaki N,Hisatome I

更新日期：2007-11-01 00:00:00